Active Ingredient Production |Purification Process | Reaction Monitoring

More efficient reaction monitoring through online measurement methods, even for pro-cesses with spectroscopically inactive components

Online process control for precise reaction endpoint determination in a purification process

Online measurement methods enable reliable reaction tracking in real time

The analysis of substance mixtures using spectroscopic measurement methods is widely used in applications in the chemical and pharmaceutical industries, among others. The main advantages are the quantitative and qualitative determination of a defined substance or parameter with high precision and reproducibility and therefore optimum process control and process reliability. Conventional methods, such as gas chromotagraphy (GC), are problematic for some types of process where precise reaction endpoint determination is crucial, primarily due to the time delay in the measurement results. This is the case with purification processes, for example.

In order to meet the strict purity requirements of the chemical, food and pharmaceutical industries, an additional purification step is often carried out during the manufacturing process. A common purification process is the washing out of impurities from a system by adding a washing solution.

The Challenge

The detectability of an impurity in the production of an organic compound is to be confirmed by the presence of a precisely defined amount of this impurity in the washing solvent at the end of the washing process. The impurity to be removed cannot be detected by spectroscopic methods but only by gas chromatography. This presents a challenge for online process monitoring, especially for process measurements that require continuous analysis or very fast analysis times. In such cases, a chromatographic separation method represents a technical limitation.




Use of online measurement technology for more efficient measurability in processes with a spectroscopically non-detectable reactant.



Scope of Application

Continuous monitoring and precise reaction endpoint determination in purification processes



Area of Application

  • Monitoring of purification processes
  • Production of active ingredients
  • Chemical and pharmaceutical Industry



  • Process Analytical Technology (PAT)
  • NIR-Spectroscopy
  • Real-Time Measurement
  • Online Spectroscopy


  • NIR-Spectroscopy

  • Online/Inline

  • Real-Time Measurement


  • Optimum process control through continuous real-time measurements
  • Compliant and safe production

The Application

During a purification process, it is necessary to extract a contaminant from the filter cake that forms during the washing process. The washing solvent after the reactor is monitored and the washing process is to be interrupted if it falls below a predefined threshold value.

Schematic representation of a filter cake wash

You want to know how this measurement task was solved the best possible way?

A more detailed description on how this application was realized using online measurement technology can be found in our detailed application report, which you can download from the info column at the top of the page.


Hellma USA Inc.
120 Terminal Drive
11803 Plainview, NY
United States

Phone: +1 5169 3908 88


Disabled, please use email.

Complete Application Note

More efficient reaction monitoring through online measurement methods, even for processes with spectroscopically inactive components


Thank you very much for your interest in our download of "More efficient reaction monitoring through online measurement methods, even for processes with spectroscopically inactive components". Please fill in the form below and we will send you the requested link to the given e-mail address.

Note: Your data will of course be treated confidentially and will not be shared with third parties. You can revoke your consent at any time by clicking on the end of each e-mail.
Required Field

Datasheet Excalibur HD FCP

Excalibur HD FCP (Datasheet EN)